Each cell has a phenome & is an independent functioning life.
The phenome is the sum of many functions, or collective life, for each cell.
The phenome is the set of all phenotypic traits expressed by a cell or organism, central to all questions in biology, in which the sum of the parts creates a whole.
Each cell has a phenome & is an independent functioning life.
The phenome is the sum of many functions, or collective life, for each cell.
The evolution of functional biology began with immune surface breakthroughs and the advent of flow cytometry, which defined CD4 T cells and enhanced the ability to combat infectious diseases. Following this, significant genome breakthroughs led to the ability to change T cell receptors and create novel therapies such as CAR-T. The era of phenome is now upon us as we increase our scope of biological understanding, enabling the engineering of new therapies with optimal functional phenomes.
In particular, today's solutions typically look at three things:
Our technologies uniquely capture aspects of the phenome required to accelerate biological solutions for thousands of labs in this next era of the phenome.
The Bruker Cellular Analysis Suite of discovery to clinical research technologies can capture the phenome, the collective sum of the parts of the cells, the phenotype, and the functional phenotype, and leverage that to pick the best whole cells and pick the best patient response.
Bruker Cellular Analysis uniquely reveals Potent and Dysfunctional Cells — highly polyfunctional cells that are early actors and orchestrators in the immune response. These rare subsets of highly functional cells can be beneficial (Potent Cells) or detrimental (Dysfunctional Cells). Detecting these cells is critical for developing more effective immune therapies and vaccines.
Potent cells are rare subsets of highly-polyfunctional cells that orchestrate the response against tumors and correlate to potency, persistence, and survival.
Dysfunctional cells are highly-polyfunctional cells that drive disease progression and correlate to inflammation, toxicity, and resistance.
The proteome is complex and requires direct detection. Dynamic in vivo biology is the captured by the proteome— the key to advancing medicines and diagnostics.
Bruker Cellular Analysis technology can uniquely reveal highly functional cells — the 5-10% of cells that are early actors of an immune response. We achieve this by detecting each cell's highly multiplexing cytokines, chemokines, and phosphoproteins.
The IsoSpark's leap in innovation allows researchers to immediately detect the most potent immune cells and leverage that response data for preclinical and translational/clinical research.
The Beacon's breakthrough single-cell functional phenotyping tells you exactly which immune/production cell functionally produces key antibodies/proteins and the receptor/clone data, with the ability to retrieve that live cell.
This leap in innovation allows researchers to immediately detect the most potent cell and leverage it for discovery and bioprocessing.
Cytokine function dictates the response of each cell to the tumor:
With the leaders from Kite Pharma and NCI: in a 20-patient non-Hodgkin Lymphoma CAR-T study, the frequency of highly functional cells (~20-25%), i.e., High PSI of each CAR-T cell therapy product, predicted response - Flow Cytometry & Bulk ELISA did not. Functional single-cell biology uniquely provides this information and can be targeted to create better products before release.
Emergency Use Authorization of AstraZeneca’s Evuseld: Researchers at Vanderbilt used our Optofluidic platform to discover the antibodies from primary human tissues. Patients given a single injection of the antibody treatment were 83% less likely to develop symptomatic cases of the coronavirus than participants who were given a placebo.
In a separate trial, patients with mild-to-moderate COVID-19 who were given one dose of antibody treatment within three days of developing symptoms had a reduced risk of developing severe disease by 88%.
Results published in Nature Medicine.
Every B cell can produce a unique antibody, and discovering the most potent antibody often requires finding the rate B cell in a highly diverse cell population.
Antibody discovery using the traditional hybridoma approach requires the immortalization of B cells by cell fusion that results in the death of >90% of B cells. This significantly reduces the chances of discovering novel antibodies against difficult targets.
Opto B Discovery workflows on the Beacon systems increase the probability of finding the best antibody by direct functional assessment of antibody products by single B cells.
Our proprietary & patented “Proteomic Barcoded” IsoCode Chip, named the Scientist's number #1 innovation, works by detecting 30+ cytokines per cell, measuring the functional phenotype of each immune cell.
This breakthrough technical innovation allows for complete single-cell functional characterization — something that was not possible before.
Our OEP fluidics uses light and millions of light-actuated pixels to move individual cells to be isolated, cultured, assayed, and exported. Each cell or clone is imaged and monitored in real-time in a NanoPen™ chamber on our OptoSelect™ chips to provide rich visual data early and often. Our Optofluidic product suite delivers cell processing and deep profiling with more information about cell function than any other technology.
Gain deeper access to in vivo biology through highly-multiplexed functional cell biology.
Instantly analyze, dissect, visualize, and export your data with a click of a button — no coding required.
Fully automate your workflow with our all-in-one, intuitive system that fits on your lab bench.
玻璃钢生产厂家郑州定做玻璃钢雕塑厂家玻璃钢酿酒文化雕塑银川城市玻璃钢雕塑设计鞍山售卖沈阳玻璃钢花盆太原步行街玻璃钢雕塑定做价格通渭玻璃钢雕塑销售宁夏玻璃钢海豚雕塑安徽环保玻璃钢雕塑优势昆明户外玻璃钢雕塑销售电话伊犁气球商场美陈装饰哪家专业商丘景观园林玻璃钢雕塑重庆人物玻璃钢雕塑制作滁州玻璃钢雕塑制作设计天津玻璃钢雕塑厂招聘信息漳州玻璃钢艺术雕塑吉林省玻璃钢雕塑阜阳景区玻璃钢雕塑室外玻璃钢彩绘雕塑定制厂家通用玻璃钢雕塑品牌企业唐山玻璃钢雕塑制作山西省商场美陈公司定西城市玻璃钢雕塑安装校园玻璃钢雕塑工厂玻璃钢吉祥物雕塑供应商上海小区玻璃钢雕塑厂家曲靖市玻璃钢雕塑定做威海校园玻璃钢雕塑安装西宁玻璃钢雕塑安装福建多彩玻璃钢雕塑生产厂家溧水玻璃钢造型雕塑香港通过《维护国家安全条例》两大学生合买彩票中奖一人不认账让美丽中国“从细节出发”19岁小伙救下5人后溺亡 多方发声单亲妈妈陷入热恋 14岁儿子报警汪小菲曝离婚始末遭遇山火的松茸之乡雅江山火三名扑火人员牺牲系谣言何赛飞追着代拍打萧美琴窜访捷克 外交部回应卫健委通报少年有偿捐血浆16次猝死手机成瘾是影响睡眠质量重要因素高校汽车撞人致3死16伤 司机系学生315晚会后胖东来又人满为患了小米汽车超级工厂正式揭幕中国拥有亿元资产的家庭达13.3万户周杰伦一审败诉网易男孩8年未见母亲被告知被遗忘许家印被限制高消费饲养员用铁锨驱打大熊猫被辞退男子被猫抓伤后确诊“猫抓病”特朗普无法缴纳4.54亿美元罚金倪萍分享减重40斤方法联合利华开始重组张家界的山上“长”满了韩国人?张立群任西安交通大学校长杨倩无缘巴黎奥运“重生之我在北大当嫡校长”黑马情侣提车了专访95后高颜值猪保姆考生莫言也上北大硕士复试名单了网友洛杉矶偶遇贾玲专家建议不必谈骨泥色变沉迷短剧的人就像掉进了杀猪盘奥巴马现身唐宁街 黑色着装引猜测七年后宇文玥被薅头发捞上岸事业单位女子向同事水杯投不明物质凯特王妃现身!外出购物视频曝光河南驻马店通报西平中学跳楼事件王树国卸任西安交大校长 师生送别恒大被罚41.75亿到底怎么缴男子被流浪猫绊倒 投喂者赔24万房客欠租失踪 房东直发愁西双版纳热带植物园回应蜉蝣大爆发钱人豪晒法院裁定实锤抄袭外国人感慨凌晨的中国很安全胖东来员工每周单休无小长假白宫:哈马斯三号人物被杀测试车高速逃费 小米:已补缴老人退休金被冒领16年 金额超20万